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1. A 26-year-old woman was diagnosed with TB by sputum Gene Xpert testing during a community health campaign three days ago and was sent to your clinic for further evaluation. She was initiated on isoniazid, ethambutol, rifampicin and pyrazin- amide. During your initial evaluation, you recom- mend an HIV test, which she obtains and turns positive. A point of care CD4 cell count shows 150 cells/mm3. When is the most appropriate time to initiate antiretroviral therapy (ART) for this patient?
2. Two months after initiation of isoniazid, rifampin, pyrazinamide, and ethambutol (HRZE) the patient complains that he feels numbness and tingling in his feet. Which of the following measures could have prevented this side effect?
3. Which of the following antiretroviral (ART) options should be dose adjusted with rifamycin therapy?
4. Match the following side effects with its most common offending medication.
Pyrazinamide
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Rifampin
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Ethambutol
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Isoniazid
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5. Which of the following is a symptom of medication-induced hepatotoxicity?