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1. A 56-year-old woman with well-controlled HIV on TDF, 3TC, and DTG is brought to the hospital by her family members because she is confused. Her vital signs are notable for BP 76/40, HR 156, RR 32, T 38.4 ̊C. Collateral history reveals that she com- plained of burning urine and back pain 1 day ago. Physical exam reveals severe tenderness on deep palpation at the costophrenic angles bilaterally. She appears septic. Which of the following interventions should be prioritized?
2. A 33-year-old man is admitted to the hospital with confusion. One day later, a diagnosis of cryptococcal meningitis is made. Intravenous amphotericin B deoxycholate is initiated. On day 5 of admission, after initial improvement, he develops fever of 38.2 (recorded twice 8 hours apart). The overnight nurse changed his IV catheter because the patient was complaining about “it being uncomfortable during infusion of medications”. He has no other com- plaints. Which of the following is the MOST likely source of sepsis in this patient?